Tim Visser, Matt Scott and Sean Lamont also ran in tries while man of the match Greig Laidlaw kicked 14 points as Scotland beat Italy 34-10 at Murrayfield.
Italy went into the match full of confidence after beating France last weekend, but it was Scotland’s aggression and attacking verve that carried the day.
In a match billed as the wooden spoon decider, Scotland, beaten 38-18 by England on the opening weekend, dominated in all areas and capitalised on a string of Italian errors.
The high point for Scotland fans came when Hogg intercepted a pass from Luciano Orquera and set off on a stunning 80m sprint for his second try in consecutive matches.
Italy’s Alessandro Zanni bundled the ball over late on for a consolation try but it came too late to spark a revival.
After Scott had a second try ruled out for a forward pass, Lamont added the final gloss to the scoreline when he picked up a loose ball and ran 50 metres for another excellent solo effort.
Meanwhile at the Stade de France Wales finally ended a run of straight defeats by beating the hosts 16-6, effectively ending French hopes of capturing the title.
Winger George North Scored a late try to seal a victory that could have been much bigger if not for careless handling errors.
France made a string of mistakes too and the crowd were jeering them even before North scored the match-winning try off a Dan Biggar chip into the left corner.
Ireland hosts England on Sunday in what could be the match that decides the title. France, the pre-tournament favorite, is the only team without a win so far.