Hundreds of activists gathered outside Mr Clegg’s home in Putney, south-west London, just before 1pm on Saturday.
UK Uncut said disabled activists had chained their wheelchairs at both ends of Parkfields Road.
The group said it will target high-profile individuals they blame for the coalition’s spending cuts, as well as holding a march through central London.
A UK Uncut supporter, Jean Sandler, 42, said: “Nick Clegg is one of the architects of austerity. He’s a millionaire and lives in a million-pound home.
“The cuts are a political choice of this government and the cabinet of out-of-touch millionaires. They are not necessary. No one voted for Cameron and Clegg’s disastrous plan that means that we end up paying for the banks’ crisis.”
It is holding street parties in 10 cities in the UK and plans to target high profile individuals and people it believes are avoiding paying tax.
UK Uncut supporter Hannah Waters said: “David Cameron has called on the country to celebrate the Jubilee with the ‘mother of all our parties’, while at the same time his government is cutting our welfare, our NHS, our rights, dismantling our future.
“Our street parties will bring the message home that these cuts are a political choice, a choice that is theirs, not ours, and we reject it.”